Ontology highlight
ABSTRACT:
SUBMITTER: Manchinu MF
PROVIDER: S-EPMC7256663 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Manchinu Maria Francesca MF Simbula Michela M Caria Cristian Antonio CA Musu Ester E Perseu Lucia L Porcu Susanna S Steri Maristella M Poddie Daniela D Frau Jessica J Cocco Eleonora E Manunza Laura L Barella Susanna S Ristaldi Maria Serafina MS
Frontiers in medicine 20200522
Beta hemoglobinopathies are widely spread monogenic lethal diseases. <i>Delta-globin</i> gene activation has been proposed as a possible approach for curing these pathologies. The therapeutic potential of delta-globin, the non-alpha component of Hemoglobin A<sub>2</sub> (α2δ2; HbA2), has been demonstrated in a mouse model of beta thalassemia, while its anti-sickling effect, comparable to that of gamma globin, was established some time ago. Here we show that the <i>delta-globin</i> mRNA level is ...[more]