Ontology highlight
ABSTRACT:
SUBMITTER: Halim L
PROVIDER: S-EPMC7257863 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Therapeutic advances in vaccines and immunotherapy 20200527
Chimeric antigen receptor (CAR) T-cell immunotherapy has achieved unprecedented efficacy in the treatment of chemotherapy-resistant or refractory B-cell malignancies. Promising results from pivotal anti-CD19 CAR T-cell phase II trials have led to landmark approvals of two CD19-specific CAR T-cell products by the United States Food and Drug Administration and European Medicines Agency. However, several issues associated with CAR T-cell treatment remain unresolved, such as the management of severe ...[more]