Moderate intensity exercise in hypoxia increases IGF-1 bioavailability and serum irisin in individuals with type 1 diabetes.
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ABSTRACT:
SUBMITTER: Zebrowska A
PROVIDER: S-EPMC7257872 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
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Moderate intensity exercise in hypoxia increases IGF-1 bioavailability and serum irisin in individuals with type 1 diabetes.
Żebrowska Aleksandra A Sikora Marcin M Konarska Anna A Zwierzchowska Anna A Kamiński Tomasz T Robins Anna A Hall Barbara B
Therapeutic advances in endocrinology and metabolism 20200527
<h4>Aim</h4>This study aimed to determine the effect of moderate intensity continuous exercise (Ex) and hypoxia (Hyp) on serum brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and its binding protein-3 (IGFBP-3), irisin and cytokines levels in patients with type 1 diabetes (T1D).<h4>Methods</h4>A total of 14 individuals with T1D (age: 28.7 ± 7.3 years) and 14 healthy adults (age: 27.1 ± 3.9 years) performed 40-min continuous Ex at moderate intensity (50% lactate thr ...[more]
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