Dataset Information

Serum Vitamin A, E and Carotenoids After 6 Months of an Individualized Nutritional Intervention in Recently Diagnosed Breast Cancer Patients

ABSTRACT: Abstract Objectives The aim of this study was to evaluate serum concentrations of retinol, carotenoids and ?-tocopherol before and after 6 mo of an individualized nutrition intervention program in recently diagnosed breast cancer patients (BCP). Methods This is a pretest-posttest study in recently diagnosed nonmetastatic BPC undergoing antineoplastic treatment. Baseline and final measurements include anthropometry, body composition (dual x-ray absorptiometry), 24 h dietary recall, and the assessment of serum retinol, carotenoids and ?-tocopherol. The individualized nutrition intervention was developed based on the macronutrient meal equivalent method, based on women's total energy expenditure, and following the WCRF/AICR guidelines, adapting 1.5 g/kg/d of protein intake, 5–9 servings of fruits and vegetables and a caloric restriction (500–1000 kcal/d) when applicable (BMI ? 25 kg/m2). Results Nineteen women between 33 and 68 years of age completed the intervention. At the time of diagnosis, 74% of the women were overweight or obese, and serum retinol was < 1.05 µmol/L in 42% (n = 8). After the intervention, BCP decreased an average of 2.67 kg of body weight (p < 0.001), and lost ?2 kg of body fat (p < 0.01). After the intervention, serum retinol increased + 0.83 µmol/L (p < 0.001) and ?-tocopherol increased + 1.89 µmol/L (p < 0.02) increased, which was positively correlated with a dietary increase of these micronutrients (p < 0.05). No difference was found for provitamin A carotenoids or xantophils (?-carotene, ?-carotene, ?-cryptoxanthin, lutein, zeaxanthin and lycopene) (p > 0.05). Conclusions The implementation of an individualized nutritional intervention program before and during antineoplastic treatment increased serum vitamin A and E concentration, improving the nutritional status of BCP. This trial was registered at clinicaltrials.gov as NCT03625635. Funding Sources JAP, ATLM received a fellowship from the National Research Council in Mexico.

SUBMITTER: Avila-Prado J

PROVIDER: S-EPMC7258246 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Similar Datasets

Project description:Aims/hypothesisThe aim of this study was to assess whether or not a theory-based behaviour change intervention delivered by trained and quality-assured lifestyle facilitators can achieve and maintain improvements in physical activity, dietary change, medication adherence and smoking cessation in people with recently diagnosed type 2 diabetes.MethodsAn explanatory randomised controlled trial was conducted in 34 general practices in Eastern England (Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen Detected Diabetes in Primary Care-Plus [ADDITION-Plus]). In all, 478 patients meeting eligibility criteria (age 40 to 69 years with recently diagnosed screen or clinically detected diabetes) were individually randomised to receive either intensive treatment (n = 239) or intensive treatment plus a theory-based behaviour change intervention led by a facilitator external to the general practice team (n = 239). Randomisation was central and independent using a partial minimisation procedure to balance stratifiers between treatment arms. Facilitators taught patients skills to facilitate change in and maintenance of key health behaviours, including goal setting, self-monitoring and building habits. Primary outcomes included physical activity energy expenditure (individually calibrated heart rate monitoring and movement sensing), change in objectively measured fruit and vegetable intake (plasma vitamin C), medication adherence (plasma drug levels) and smoking status (plasma cotinine levels) at 1 year. Measurements, data entry and laboratory analysis were conducted with staff unaware of participants' study group allocation.ResultsOf 475 participants still alive, 444 (93%; intervention group 95%, comparison group 92%) attended 1-year follow-up. There were no significant differences between groups in physical activity (difference: +1.50 kJ kg(-1) day(-1); 95% CI -1.74, 4.74), plasma vitamin C (difference: -3.84 μmol/l; 95% CI -8.07, 0.38), smoking (OR 1.37; 95% CI 0.77, 2.43) and plasma drug levels (difference in metformin levels: -119.5 μmol/l; 95% CI -335.0, 95.9). Cardiovascular risk factors and self-reported behaviour improved in both groups with no significant differences between groups.Conclusions/interpretationFor patients with recently diagnosed type 2 diabetes receiving intensive treatment in UK primary care, a facilitator-led individually tailored behaviour change intervention did not improve objectively measured health behaviours or cardiovascular risk factors over 1 year.Trial registrationISRCTN99175498 FUNDING: The trial is supported by the Medical Research Council, the Wellcome Trust, National Health Service R&D support funding (including the Primary Care Research and Diabetes Research Networks) and National Institute of Health Research under its Programme Grants for Applied Research scheme. The Primary Care Unit is supported by NIHR Research funds. Bio-Rad provided equipment for HbA1c testing during the screening phase.

Project description:BackgroundThere is limited knowledge regarding the potential benefits of physical activity in patients with metastatic breast cancer.ObjectiveThe Advanced stage Breast cancer and Lifestyle Exercise (ABLE) Trial aimed to assess the feasibility of a physical activity intervention in women with metastatic breast cancer and to explore the effects of physical activity on functional, psychological, and clinical parameters.MethodsThe ABLE Trial was a single-arm, 6-month intervention study with a home-based, unsupervised, and personalized walking program using an activity tracker. At baseline and 6 months, we assessed anthropometrics, functional fitness, physical activity level, sedentary behavior, quality of life, fatigue, and tumor progression. Paired proportions were compared using the McNemar test and changes of parameters during the intervention were analyzed using the Wilcoxon signed-rank test, the Mann-Whitney test, and Spearman rank correlations.ResultsOverall, 49 participants (mean age 55 years; recruitment rate 94%) were enrolled and 96% adhered to the exercise prescription (attrition rate 2%). Statistically significant improvements in the 6-minute walking distance test (+7%, P<.001) and isometric quadriceps strength (+22%, P<.001), as well as decreases in body mass index (-2.5%, P=.03) and hip circumference (-4.0%, P<.001) were observed at 6 months. Quality of life remained stable and a nonstatistically significant decrease (-16%, P=.07) in fatigue was observed.ConclusionsThe high recruitment and adherence rates suggest the willingness of patients with metastatic breast cancer to participate in a physical activity program. The beneficial outcomes regarding physical fitness and anthropometry of this unsupervised physical activity program may encourage these patients to maintain a physically active lifestyle. Future randomized controlled trials with larger sample sizes are warranted.Trial registrationClinicalTrials.gov NCT03148886; https://clinicaltrials.gov/ct2/show/NCT03148886.

Dataset Information

Serum Vitamin A, E and Carotenoids After 6 Months of an Individualized Nutritional Intervention in Recently Diagnosed Breast Cancer Patients

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets