Ontology highlight
ABSTRACT:
SUBMITTER: Prabhu VV
PROVIDER: S-EPMC7259201 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Prabhu Varun V VV Madhukar Neel S NS Gilvary Coryandar C Kline C Leah B CLB Oster Sophie S El-Deiry Wafik S WS Elemento Olivier O Doherty Faye F VanEngelenburg Alexander A Durrant Jessica J Tarapore Rohinton S RS Deacon Sean S Charter Neil N Jung Jinkyu J Park Deric M DM Gilbert Mark R MR Rusert Jessica J Wechsler-Reya Robert R Arrillaga-Romany Isabel I Batchelor Tracy T TT Wen Patrick Y PY Oster Wolfgang W Allen Joshua E JE
Clinical cancer research : an official journal of the American Association for Cancer Research 20181217 7
<h4>Purpose</h4>Dopamine receptor D2 (DRD2) is a G protein-coupled receptor antagonized by ONC201, an anticancer small molecule in clinical trials for high-grade gliomas and other malignancies. DRD5 is a dopamine receptor family member that opposes DRD2 signaling. We investigated the expression of these dopamine receptors in cancer and their influence on tumor cell sensitivity to ONC201.<h4>Experimental design</h4>The Cancer Genome Atlas was used to determine DRD2/DRD5 expression broadly across ...[more]