Ontology highlight
ABSTRACT:
SUBMITTER: Suomivuori CM
PROVIDER: S-EPMC7259329 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Suomivuori Carl-Mikael CM Latorraca Naomi R NR Wingler Laura M LM Eismann Stephan S King Matthew C MC Kleinhenz Alissa L W ALW Skiba Meredith A MA Staus Dean P DP Kruse Andrew C AC Lefkowitz Robert J RJ Dror Ron O RO
Science (New York, N.Y.) 20200201 6480
Biased signaling, in which different ligands that bind to the same G protein-coupled receptor preferentially trigger distinct signaling pathways, holds great promise for the design of safer and more effective drugs. Its structural mechanism remains unclear, however, hampering efforts to design drugs with desired signaling profiles. Here, we use extensive atomic-level molecular dynamics simulations to determine how arrestin bias and G protein bias arise at the angiotensin II type 1 receptor. The ...[more]