Ontology highlight
ABSTRACT:
SUBMITTER: Aguilar MT
PROVIDER: S-EPMC7259454 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Hepatic medicine : evidence and research 20200525
Primary biliary cholangitis (PBC) is a rare autoimmune cholestatic liver disease that may progress to fibrosis or cirrhosis. Treatment options are currently limited. Ursodeoxycholic acid (UDCA) remains first-line therapy and has been proven to normalize serum biochemistries, halt histologic disease progression, and lead to patient survival comparable to the general population. Obeticholic acid (OCA) was recently approved as adjunct therapy in PBC patients with inadequate response or intolerance ...[more]