Age, sex and disease-specific associations between resting heart rate and cardiovascular mortality in the UK BIOBANK.

ABSTRACT:

Objective

To define the sex, age, and disease-specific associations of resting heart rate (RHR) with cardiovascular and mortality outcomes in 502,534 individuals from the UK Biobank over 7-12 years of prospective follow-up.

Methods

The main outcomes were all-cause, cardiovascular, and ischaemic heart disease mortality. Additional outcomes included incident acute myocardial infarction (AMI), fatal AMI, and cancer mortality. We considered a wide range of confounders and the effects of competing hazards. Results are reported as hazard ratios (HR) for all-cause mortality and sub-distribution hazard ratios (SHR) for other outcomes with corresponding 95% confidence intervals (CI) per 10bpm increment of RHR.

Results

In men, for every 10bpm increase of RHR there was 22% (HR 1

SUBMITTER: Raisi-Estabragh Z 

PROVIDER: S-EPMC7259773 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature