Ontology highlight
ABSTRACT:
SUBMITTER: Burke CM
PROVIDER: S-EPMC7259791 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Burke Cassandra M CM Mark Kenneth M K KMK Kun Judit J Beauchemin Kathryn S KS Supattapone Surachai S
PLoS pathogens 20200518 5
Prions are unorthodox infectious agents that replicate by templating misfolded conformations of a host-encoded glycoprotein, collectively termed PrPSc. Prion diseases are invariably fatal and currently incurable, but oral drugs that can prolong incubation times in prion-infected mice have been developed. Here, we tested the efficacy of combination therapy with two such drugs, IND24 and Anle138b, in scrapie-infected mice. The results indicate that combination therapy was no more effective than ei ...[more]