Ontology highlight
ABSTRACT:
SUBMITTER: Porter JR
PROVIDER: S-EPMC7259954 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Porter Justin R JR Meller Artur A Zimmerman Maxwell I MI Greenberg Michael J MJ Bowman Gregory R GR
eLife 20200529
Myosin motor domains perform an extraordinary diversity of biological functions despite sharing a common mechanochemical cycle. Motors are adapted to their function, in part, by tuning the thermodynamics and kinetics of steps in this cycle. However, it remains unclear how sequence encodes these differences, since biochemically distinct motors often have nearly indistinguishable crystal structures. We hypothesized that sequences produce distinct biochemical phenotypes by modulating the relative p ...[more]