Ontology highlight
ABSTRACT:
SUBMITTER: Vais H
PROVIDER: S-EPMC7259957 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Vais Horia H Wang Min M Mallilankaraman Karthik K Payne Riley R McKennan Chris C Lock Jeffrey T JT Spruce Lynn A LA Fiest Carly C Chan Matthew Yan-Lok MY Parker Ian I Seeholzer Steven H SH Foskett J Kevin JK Mak Don-On Daniel DD
eLife 20200518
Modulating cytoplasmic Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>) by endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptor (InsP<sub>3</sub>R) Ca<sup>2+</sup>-release channels is a universal signaling pathway that regulates numerous cell-physiological processes. Whereas much is known regarding regulation of InsP<sub>3</sub>R activity by cytoplasmic ligands and processes, its regulation by ER-luminal Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>ER</ ...[more]