Ontology highlight
ABSTRACT:
SUBMITTER: Pende M
PROVIDER: S-EPMC7259959 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Science advances 20200529 22
Tissue clearing combined with deep imaging has emerged as a powerful alternative to classical histological techniques. Whereas current techniques have been optimized for imaging selected nonpigmented organs such as the mammalian brain, natural pigmentation remains challenging for most other biological specimens of larger volume. We have developed a fast DEpigmEntation-Plus-Clearing method (DEEP-Clear) that is easily incorporated in existing workflows and combines whole system labeling with a spe ...[more]