Ontology highlight
ABSTRACT:
SUBMITTER: Guedan S
PROVIDER: S-EPMC7260017 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Guedan Sonia S Madar Aviv A Casado-Medrano Victoria V Shaw Carolyn C Wing Anna A Liu Fang F Young Regina M RM June Carl H CH Posey Avery D AD
The Journal of clinical investigation 20200601 6
Chimeric antigen receptor-T (CAR-T) cell therapies can eliminate relapsed and refractory tumors, but the durability of antitumor activity requires in vivo persistence. Differential signaling through the CAR costimulatory domain can alter the T cell metabolism, memory differentiation, and influence long-term persistence. CAR-T cells costimulated with 4-1BB or ICOS persist in xenograft models but those constructed with CD28 exhibit rapid clearance. Here, we show that a single amino acid residue in ...[more]