Immunological and Clinical Phenotyping in Primary Antibody Deficiencies: a Growing Disease Spectrum.

ABSTRACT:

Purpose

Although common variable immunodeficiency (CVID) is considered the most prevalent symptomatic primary antibody deficiency (PAD), there is a population with symptomatic PADs that do not meet criteria for CVID. We analyzed clinical and immunological profiles of patients with different PADs to better understand the differences and similarities between CVID and other PADs.

Methods

We extracted clinical and laboratory data of patients with PADs from electronic medical records. Patients were categorized into CVID, IgG subclass 2 deficiency (IgG2D), IgG deficiency (IgGD), and specific antibody deficiency (sAbD) based on basal immunoglobulin levels and pneumococcal vaccine responses. We compared clinical and immunological characteristics in these groups.

Results

All p

SUBMITTER: Shin JJ 

PROVIDER: S-EPMC7260109 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature