Ontology highlight
ABSTRACT:
SUBMITTER: Mucker EM
PROVIDER: S-EPMC7260227 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Mucker Eric M EM Karmali Priya P PP Vega Jerel J Kwilas Steven A SA Wu Hua H Joselyn Matthew M Ballantyne John J Sampey Darryl D Mukthavaram Rajesh R Sullivan Eddie E Chivukula Pad P Hooper Jay W JW
Scientific reports 20200529 1
The use of nucleic acid as a drug substance for vaccines and other gene-based medicines continues to evolve. Here, we have used a technology originally developed for mRNA in vivo delivery to enhance the immunogenicity of DNA vaccines. We demonstrate that neutralizing antibodies produced in rabbits and nonhuman primates injected with lipid nanoparticle (LNP)-formulated Andes virus or Zika virus DNA vaccines are elevated over unformulated vaccine. Using a plasmid encoding an anti-poxvirus monoclon ...[more]