Evolution and structure of clinically relevant gene fusions in multiple myeloma.
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ABSTRACT:
SUBMITTER: Foltz SM
PROVIDER: S-EPMC7260243 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Evolution and structure of clinically relevant gene fusions in multiple myeloma.
Foltz Steven M SM Gao Qingsong Q Yoon Christopher J CJ Sun Hua H Yao Lijun L Li Yize Y Jayasinghe Reyka G RG Cao Song S King Justin J Kohnen Daniel R DR Fiala Mark A MA Ding Li L Vij Ravi R
Nature communications 20200529 1
Multiple myeloma is a plasma cell blood cancer with frequent chromosomal translocations leading to gene fusions. To determine the clinical relevance of fusion events, we detect gene fusions from a cohort of 742 patients from the Multiple Myeloma Research Foundation CoMMpass Study. Patients with multiple clinic visits enable us to track tumor and fusion evolution, and cases with matching peripheral blood and bone marrow samples allow us to evaluate the concordance of fusion calls in patients with ...[more]
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