Dataset Information

Patient-reported measures of well-being in older multiple myeloma patients: use of secondary data source.

ABSTRACT: BACKGROUND:Changes in well-being of patients with multiple myeloma (MM) before and after diagnosis have not been quantified. AIMS:Explore the use of secondary data to examine the changes in the well-being of older patients with MM. METHODS:We used the Health and Retirement Study (HRS), linked to Medicare claims to identify older MM patients. We compared patient-reported measures (PRM), including physical impairment, sensory impairment, and patient experience (significant pain, self-rated health, depression) in the interviews before and after MM diagnosis using McNemar's test. We propensity-matched each MM patient to five HRS participants without MM diagnosis based on baseline characteristics. We compared the change in PRM between the MM patients and their matches. RESULTS:We identified 92 HRS patients with MM diagnosis (mean age?=?74.6, SD?=?8.4). Among the surviving patients, there was a decline in well-being across most measures, including ADL difficulty (23% to 40%, p value?=?0.016), poor or fair self-rated health (38% to 61%, p value?=?0.004), and depression (15% to 30%, p value?=?0.021). Surviving patients reported worse health than participants without MM across most measures, including ADL difficulty (40% vs. 27%, p value?=?0.04), significant pain (38% vs. 22%, p value?=?0.01), and depression (29% vs. 11%, p value?=?0.003). DISCUSSION:Secondary data were used to identify patients with MM diagnosis, and examine changes across multiple measures of well-being. MM diagnosis negatively affects several aspects of patients' well-being, and these declines are larger than those experienced by similar participants without MM. CONCLUSION:The results of this study are valuable addition to understanding the experience of patients with MM, despite several data limitations.

SUBMITTER: Cenzer I

PROVIDER: S-EPMC7260254 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Patient-reported measures of well-being in older multiple myeloma patients: use of secondary data source.

Cenzer Irena I Berger Karin K Rodriguez Annette M AM Ostermann Helmut H Covinsky Kenneth E KE

Aging clinical and experimental research 20200122 6

<h4>Background</h4>Changes in well-being of patients with multiple myeloma (MM) before and after diagnosis have not been quantified.<h4>Aims</h4>Explore the use of secondary data to examine the changes in the well-being of older patients with MM.<h4>Methods</h4>We used the Health and Retirement Study (HRS), linked to Medicare claims to identify older MM patients. We compared patient-reported measures (PRM), including physical impairment, sensory impairment, and patient experience (significant pa ...[more]

PMID: 31970671

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Project description:ObjectiveThe subjective experience of psychotic patients toward treatment is a key factor in medication adherence, quality of life, and clinical outcome. The aim of this study was to assess the subjective well-being in patients with schizophrenia and to examine its relationship with the presence and severity of depressive symptoms.MethodsA multicenter, cross-sectional study was conducted with clinically stable outpatients diagnosed with schizophrenia. The Subjective Well-Being under Neuroleptic Scale - short version (SWN-K) and the Calgary Depression Scale for Schizophrenia (CDSS) were used to gather information on well-being and the presence and severity of depressive symptoms, respectively. Spearman's rank correlation was used to assess the associations between the SWN-K total score, its five subscales, and the CDSS total score. Discriminative validity was evaluated against that criterion by analysing the area under the curve (AUC).ResultsNinety-seven patients were included in the study. Mean age was 35 years (standard deviation = 10) and 72% were male. Both the total SWN-K scale and its five subscales correlated inversely and significantly with the CDSS total score (P < 0.0001). The highest correlation was observed for the total SWN-K (Spearman's rank order correlation [rho] = -0.59), being the other correlations: mental functioning (-0.47), social integration (-0.46), emotional regulation (-0.51), physical functioning (-0.48), and self-control (-0.41). A total of 33 patients (34%) were classified as depressed. Total SWN-K showed the highest AUC when discriminating between depressive severity levels (0.84), followed by emotional regulation (0.80), social integration (0.78), physical functioning and self-control (0.77), and mental functioning (0.73). Total SWN-K and its five subscales showed a significant linear trend against CDSS severity levels (P < 0.001).ConclusionThe presence of moderate to severe depressive symptoms was relatively high, and correlated inversely with patients' subjective well-being. Routine assessment of patient-reported measures in patients with schizophrenia might reduce potential discrepancy between patient and physician assessment, increase therapeutic alliance, and improve outcome.

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Dataset Information

Patient-reported measures of well-being in older multiple myeloma patients: use of secondary data source.

Publications

Patient-reported measures of well-being in older multiple myeloma patients: use of secondary data source.

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