Endothelial dysfunction is an early indicator of sepsis and neutrophil degranulation of septic shock in surgical patients.
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ABSTRACT:
SUBMITTER: Martin-Fernandez M
PROVIDER: S-EPMC7260414 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
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Endothelial dysfunction is an early indicator of sepsis and neutrophil degranulation of septic shock in surgical patients.
Martin-Fernandez M M Vaquero-Roncero L M LM Almansa R R Gómez-Sánchez E E Martín S S Tamayo E E Esteban-Velasco M C MC Ruiz-Granado P P Aragón M M Calvo D D Rico-Feijoo J J Ortega A A Gómez-Pesquera E E Lorenzo-López M M López J J Doncel C C González-Sanchez C C Álvarez D D Zarca E E Ríos-Llorente A A Diaz-Alvarez A A Sanchez-Barrado E E Andaluz-Ojeda D D Calvo-Vecino J M JM Muñoz-Bellvís L L Gomez-Herreras J I JI Abad-Molina C C Bermejo-Martin J F JF Aldecoa C C Heredia-Rodríguez M M
BJS open 20200219 3
<h4>Background</h4>Stratification of the severity of infection is currently based on the Sequential Organ Failure Assessment (SOFA) score, which is difficult to calculate outside the ICU. Biomarkers could help to stratify the severity of infection in surgical patients.<h4>Methods</h4>Levels of ten biomarkers indicating endothelial dysfunction, 22 indicating emergency granulopoiesis, and six denoting neutrophil degranulation were compared in three groups of patients in the first 12 h after diagno ...[more]
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