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Pulmonary delivery of nanostructured lipid carriers for effective repurposing of salinomycin as an antiviral agent.

ABSTRACT: Coronavirus disease outbreak caused a severe public health burden all over the world. Salinomycin (SAL) is a broad-spectrum antibiotic that had drawn attention in selective targeting of cancer and viral infections. Recent drug screen identified SAL as a potent antiviral agent against SARS-CoV-2. In this hypothesis, we discuss the potential of pulmonary delivery of SAL using nanostructured lipid carriers (NLCs) against SARS-CoV-2.

SUBMITTER: Pindiprolu SKSS

PROVIDER: S-EPMC7260485 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Pulmonary delivery of nanostructured lipid carriers for effective repurposing of salinomycin as an antiviral agent.

Pindiprolu Sai Kiran S S SKSS Kumar Chirravuri S Phani CSP Kumar Golla Venu Sampath VS P Likitha L K Shreyas Chandra SC S K Esub Basha EB R K Ramachandra R

Medical hypotheses 20200530

Coronavirus disease outbreak caused a severe public health burden all over the world. Salinomycin (SAL) is a broad-spectrum antibiotic that had drawn attention in selective targeting of cancer and viral infections. Recent drug screen identified SAL as a potent antiviral agent against SARS-CoV-2. In this hypothesis, we discuss the potential of pulmonary delivery of SAL using nanostructured lipid carriers (NLCs) against SARS-CoV-2. ...[more]

PMID: 32516655

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