Unknown

Dataset Information

0

Higher BMI is linked to an increased risk of heart attacks in European adults: a Mendelian randomisation study.


ABSTRACT: BACKGROUND:BMI has been implicated as a risk factor for heart disease as a whole in multiple studies. Heart attack is one of the common complications of this disease. The aim of this study is to explore if elevated level of BMI causes an increase in the risk of heart attacks. METHODS:We used two Mendelian randomisation (MR) methods: inverse variance weighted estimation and robust adjusted profile score (RAPS) on the basis of summary data of adulthood BMI from Genetic Investigation of Anthropometric Traits consortium and heart attack data from the UK Biobank. BMI associated single nucleotide polymorphisms (SNPs) were used as instrumental variables. RESULTS:Seventy-two independent SNPs were associated with BMI (P?

SUBMITTER: Adams B 

PROVIDER: S-EPMC7260786 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Higher BMI is linked to an increased risk of heart attacks in European adults: a Mendelian randomisation study.

Adams Benjamin B   Jacocks Lauren L   Guo Hui H  

BMC cardiovascular disorders 20200529 1


<h4>Background</h4>BMI has been implicated as a risk factor for heart disease as a whole in multiple studies. Heart attack is one of the common complications of this disease. The aim of this study is to explore if elevated level of BMI causes an increase in the risk of heart attacks.<h4>Methods</h4>We used two Mendelian randomisation (MR) methods: inverse variance weighted estimation and robust adjusted profile score (RAPS) on the basis of summary data of adulthood BMI from Genetic Investigation  ...[more]

Similar Datasets

| S-EPMC3136158 | biostudies-literature
| S-EPMC5594424 | biostudies-literature
| S-EPMC5931085 | biostudies-other
| S-EPMC10290077 | biostudies-literature
| S-EPMC5931494 | biostudies-literature
| S-EPMC6716818 | biostudies-literature
| S-EPMC8404179 | biostudies-literature
| S-EPMC8789289 | biostudies-literature
| S-EPMC4919785 | biostudies-literature
| S-EPMC8310793 | biostudies-literature