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ABSTRACT: Purpose
As exome and genome sequencing (ES/GS) enters the clinic, there is an urgent need to understand the psychological effects of test result disclosure. Through a Clinical Sequencing Exploratory Research (CSER), phase 1 (CSER1) Consortium collaboration, we evaluated participants' psychological outcomes across multiple clinical settings.Methods
We conducted a random effects meta-analysis of state anxiety (Hospital Anxiety and Depression Scale [HADS]/Generalized Anxiety Disorder 7-item), depressive symptoms (HADS/Personal Health Questionnaire 9-item), and multidimensional impact (i.e., test-related distress, uncertainty and positive impact: modified Multidimensional Impact of Cancer Risk Assessment/Feelings About Genomic Testing Results scale).Results
Anxiety and depression did not increase significantly following test result disclosure. Meta-analyses examining mean differences from pre- to postdisclosure revealed an overall trend for a decrease in participants' anxiety. We observed low levels of test-related distress and perceptions of uncertainty in some populations (e.g., pediatric patients) and a wide range of positive responses.Conclusion
Our findings across multiple clinical settings suggest no clinically significant psychological harms from the return of ES/GS results. Some populations may experience low levels of test-related distress or greater positive psychological effects. Future research should further investigate the reasons for test-related psychological response variation.
SUBMITTER: Robinson JO
PROVIDER: S-EPMC7260995 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Robinson Jill O JO Wynn Julia J Biesecker Barbara B Biesecker Leslie G LG Bernhardt Barbara B Brothers Kyle B KB Chung Wendy K WK Christensen Kurt D KD Green Robert C RC McGuire Amy L AL Hart M Ragan MR Griesemer Ida I Patrick Donald L DL Rini Christine C Veenstra David D Cronin Angel M AM Gray Stacy W SW
Genetics in medicine : official journal of the American College of Medical Genetics 20190613 12
<h4>Purpose</h4>As exome and genome sequencing (ES/GS) enters the clinic, there is an urgent need to understand the psychological effects of test result disclosure. Through a Clinical Sequencing Exploratory Research (CSER), phase 1 (CSER1) Consortium collaboration, we evaluated participants' psychological outcomes across multiple clinical settings.<h4>Methods</h4>We conducted a random effects meta-analysis of state anxiety (Hospital Anxiety and Depression Scale [HADS]/Generalized Anxiety Disorde ...[more]