A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory.
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ABSTRACT:
SUBMITTER: Zhou M
PROVIDER: S-EPMC7261007 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
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A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory.
Zhou Mu M Liu Zhihui Z Melin Maxwell D MD Ng Yi Han YH Xu Wei W Südhof Thomas C TC
Nature neuroscience 20181022 11
The formation and retrieval of conditioned fear memories critically depend on the amygdala. Here we identify an inhibitory projection from somatostatin-positive neurons in the central amygdala to parvalbumin-positive neurons in the zona incerta that is required for both recent and remote fear memories. Thus, the amygdala inhibitory input to parvalbumin-positive neurons in the zona incerta, a nucleus not previously implicated in fear memory, is an essential component of the fear memory circuitry. ...[more]
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