Ontology highlight
ABSTRACT:
SUBMITTER: Kreuder AK
PROVIDER: S-EPMC7261088 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Kreuder Ann-Kathrin AK Scheele Dirk D Schultz Johannes J Hennig Juergen J Marsh Nina N Dellert Torge T Ettinger Ulrich U Philipsen Alexandra A Babasiz Mari M Herscheid Angela A Remmersmann Laura L Stirnberg Ruediger R Stöcker Tony T Hurlemann René R
Proceedings of the National Academy of Sciences of the United States of America 20200508 21
Benzodiazepines (BZDs) represent the gold standard of anxiolytic pharmacotherapy; however, their clinical benefit is limited by side effects and addictive potential. Consequently, there is an urgent need to develop novel and safe anxiolytics. The peptide hormone oxytocin (OXT) exhibits anxiolytic-like properties in animals and humans, but whether OXT and BZDs share similar effects on the neural circuitry of fear is unclear. Therefore, the rationale of this ultra-high-field functional MRI (fMRI) ...[more]