Ontology highlight
ABSTRACT:
SUBMITTER: Gomes I
PROVIDER: S-EPMC7261131 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20200511 21
Opioids, such as morphine and fentanyl, are widely used for the treatment of severe pain; however, prolonged treatment with these drugs leads to the development of tolerance and can lead to opioid use disorder. The "Opioid Epidemic" has generated a drive for a deeper understanding of the fundamental signaling mechanisms of opioid receptors. It is generally thought that the three types of opioid receptors (μ, δ, κ) are activated by endogenous peptides derived from three different precursors: Proo ...[more]