Ontology highlight
ABSTRACT:
SUBMITTER: Woll AK
PROVIDER: S-EPMC7261286 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Wöll Anna K AK Hubbuch Jürgen J
Bioprocess and biosystems engineering 20200320 7
Formulation conditions have a significant influence on the degree of freeze/thaw (FT) stress-induced protein instabilities. Adding cryoprotectants might stabilize the induced FT stress instabilities. However, a simple preservation of protein stability might be insufficient and further methods are necessary. This study aims to evaluate the addition of a heat cycle following FT application as a function of different cryoprotectants with lysozyme as exemplary protein. Sucrose and glycerol were show ...[more]