Placental DNA methylation changes associated with maternal prepregnancy BMI and gestational weight gain.

ABSTRACT: BACKGROUND:Maternal obesity prior to or during pregnancy influences fetal growth, predisposing the offspring to increased risk for obesity across the life course. Placental epigenetic mechanisms may underlie these associations. We conducted an epigenome-wide association study to identify placental DNA methylation changes associated with maternal prepregnancy body mass index (BMI) and rate of gestational weight gain at first (GWG1), second (GWG2), and third trimester (GWG3). METHOD:Participants of the NICHD Fetal Growth Studies with genome-wide placental DNA methylation (n?=?301) and gene expression (n?=?75) data were included. Multivariable-adjusted regression models were used to test the associations of 1?kg/m2 increase in prepregnancy BMI or 1?kg/week increase in GWG with DNA methylation levels. Genes harboring top differentially methylated CpGs (FDR P?

SUBMITTER: Shrestha D 

PROVIDER: S-EPMC7261634 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature