The A4 study: β-amyloid and cognition in 4432 cognitively unimpaired adults.

ABSTRACT:

Objective

To clarify the preclinical stage of Alzheimer's disease by estimating when β-amyloid accumulation first becomes associated with changes in cognition.

Methods

Here we studied a large group (N = 4432) of cognitively unimpaired individuals who were screened for inclusion in the A4 trial (age 65-85) to assess the effect of subthreshold levels of β-amyloid on cognition and to identify which cognitive domains first become affected.

Results

β-amyloid accumulation was linked to significant cognitive dysfunction in cognitively unimpaired participants with subthreshold levels of β-amyloid in multiple measures of memory (Logical Memory Delayed Recall, P = 0.03; Free and Cued Selective Reminding Test, P < 0.001), the Preclinical Alzheimer's Cognitive Composite (P = 0.01

SUBMITTER: Insel PS 

PROVIDER: S-EPMC7261742 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature