Heritability of alpha and sensorimotor network changes in temporal lobe epilepsy.

ABSTRACT:

Objective

Electroencephalography (EEG) features in the alpha band have been shown to differ between people with epilepsy and healthy controls. Here, in a group of patients with mesial temporal lobe epilepsy (mTLE), we seek to confirm these EEG features, and using simultaneous functional magnetic resonance imaging, we investigate whether brain networks related to the alpha rhythm differ between patients and healthy controls. Additionally, we investigate whether alpha abnormalities are found as an inherited endophenotype in asymptomatic relatives.

Methods

We acquired scalp EEG and simultaneous EEG and functional magnetic resonance imaging in 24 unrelated patients with unilateral mTLE, 23 asymptomatic first-degree relatives of patients with mTLE, and 32 healthy controls. We com

SUBMITTER: Yaakub SN 

PROVIDER: S-EPMC7261746 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature