MiR-449a attenuates autophagy of T-cell lymphoma cells by downregulating ATG4B expression.
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ABSTRACT:
SUBMITTER: Zhang N
PROVIDER: S-EPMC7262515 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
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MiR-449a attenuates autophagy of T-cell lymphoma cells by downregulating ATG4B expression.
Zhang Nan N Qiu Ling L Li Tao T Wang Xiao X Deng Rui R Yi Hai H Su Yi Y Fan Fang-Yi FY
BMB reports 20200501 5
Increasing evidence suggests the role of miR-449a in the regulation of tumorigenesis and autophagy. Autophagy plays an important role in the malignancy of T-cell lymphoma. However, it is still unknown whether miR-449a is associated with autophagy to regulate the malignancy of T-cell lymp homa. In this study, we for the first time demonstrated that miR-449a enhanced apoptosis of T-cell lymphoma cells by decreasing the degree of autophagy. Further, miR-449a downregulated autophagy-associated 4B (A ...[more]
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