Dataset Information

Dataset on the degradation of losartan by TiO2-photocatalysis and UVC/persulfate processes.

ABSTRACT: Losartan is a highly consumed antihypertensive worldwide and commonly found in effluents of municipal wastewater treatment plants. In the environment, losartan can promote harmful effects on organisms. Thus, an option to face this pollutant is the treatment by photochemical advanced oxidation processes. This dataset has two main components: 1) theoretical calculations on reactivity indexes for losartan, and 2) degradation of the pollutant throughout TiO2-photocatalysis and UVC/persulfate (UVC/PS). The first part of the work presents the data about HOMO and LUMO energies, optimized geometry, dipolar moment, HOMO/LUMO energy gap and total density distribution, in addition to ionization energy, electron affinity, chemical potential, hardness, softness and electrophilicity for losartan. Meanwhile, the second one depicts information on the routes involved in the degradation of the pharmaceutical by the oxidation processes, mineralization, toxicity evolution and losartan removal from a complex matrix (synthetic fresh urine). The data reported herein may be utilized for further researches related to elimination of pharmaceuticals in primary pollution sources such as urine. Moreover, this work also provides experimental and theoretical data useful for the understanding of the response of losartan to oxidative and photochemical processes.

SUBMITTER: Guateque-Londono JF

PROVIDER: S-EPMC7262553 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Dataset on the degradation of losartan by TiO<sub>2</sub>-photocatalysis and UVC/persulfate processes.

Guateque-Londoño John F JF Serna-Galvis Efraím A EA Silva-Agredo Javier J Ávila-Torres Yenny Y Torres-Palma Ricardo A RA

Data in brief 20200514

Losartan is a highly consumed antihypertensive worldwide and commonly found in effluents of municipal wastewater treatment plants. In the environment, losartan can promote harmful effects on organisms. Thus, an option to face this pollutant is the treatment by photochemical advanced oxidation processes. This dataset has two main components: 1) theoretical calculations on reactivity indexes for losartan, and 2) degradation of the pollutant throughout TiO<sub>2</sub>-photocatalysis and UVC/persulf ...[more]

PMID: 32490071

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Project description:The consumption of contaminated shellfish with marine toxins causes adverse socioeconomical, environmental and health impacts. The marine toxin okadaic acid (OA) provokes diarrhetic shellfish poisoning (DSP) syndrome characterized by severe gastrointestinal symptoms. Therefore, there is increasing interest in removing these toxins from the marine environment to protect shellfish harvesting sites. Photocatalysis is proposed as an efficient method to detoxify the marine environment. In this study, Prorocentrum lima was used to produce high purity DSP toxins, in particular OA, for degradation studies. The profiling, characterization and quantification of DSP toxins in the culture of P. lima were achieved by ultrahigh performance liquid chromatography coupled to quadrupole-time of flight mass spectrometry (UPLC-QTOF-MSE) for accurate-mass full spectrum acquisition data. The effectiveness of UV/TiO2 system to degrade OA in seawater was assessed in lab-scale experiments and identification of transformation products was proposed based on the data obtained during analysis by UPLC-QTOF-MSE. The detoxification potential of the UV/TiO2 system was investigated using the phosphatase inhibition assay. Sufficient amount of high-purity OA (25?mg, >90% purity) was produced in-house for use in photocatalysis experiments by simple reversed-phase flash chromatography. Complete degradation of OA was observed in seawater after 30?min and 7.5?min in deionized water. The rate constants fitted with the pseudo-first order kinetic model (R2?>?0.96). High-resolution mass spectrometry analysis of the photocatalyzed OA allowed tentative identification of four transformation products. Detoxification was achieved in parallel with the degradation of OA in deionized water and artificial ocean water (?20?min) but not for seawater. Overall, results suggest that UV/TiO2 photocatalysis can be an effective approach for degrading OA and their TPs in the marine environment. To the best of our knowledge, this is the first report on the use of photocatalysis to degrade marine toxins and its promising potential to protect shellfish harvesting sites.

Dataset Information

Dataset on the degradation of losartan by TiO2-photocatalysis and UVC/persulfate processes.

Publications

Dataset on the degradation of losartan by TiO<sub>2</sub>-photocatalysis and UVC/persulfate processes.

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