Sperm Originated Chromatin Imprints and LincRNAs in Organismal Development and Cancer.

ABSTRACT: Importance of sperm-derived transcripts and chromatin imprints in organismal development is poorly investigated. Here using an integrative approach, we show that human sperm transcripts are equally important as oocyte. Sperm-specific and sperm-oocyte common transcripts carry distinct chromatin structures at their promoters correlating with corresponding transcript levels in sperm. Interestingly, sperm-specific H3K4me3 patterns at the lincRNA promoters are not maintained in the germ layers and somatic tissues. However, bivalent chromatin at the sperm-specific protein-coding gene promoters is maintained throughout the development. Sperm-specific transcripts reach their peak expression during zygotic genome activation, whereas sperm-oocyte common transcripts are present during early preimplan

SUBMITTER: Subhash S 

PROVIDER: S-EPMC7262563 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature