Ontology highlight
ABSTRACT:
SUBMITTER: Chen C
PROVIDER: S-EPMC7262670 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Cell reports 20191201 12
Fetal hematopoietic stem cells (HSCs) undergo a developmental switch to become adult HSCs with distinct functional properties. To better understand the molecular mechanisms underlying the developmental switch, we have conducted deep sequencing of the 3D genome, epigenome, and transcriptome of fetal and adult HSCs in mouse. We find that chromosomal compartments and topologically associating domains (TADs) are largely conserved between fetal and adult HSCs. However, there is a global trend of incr ...[more]