Ontology highlight
ABSTRACT:
SUBMITTER: Diver MM
PROVIDER: S-EPMC7262954 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20190905 6460
The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary detector of environmental cold and an important target for treating pathological cold hypersensitivity. Here, we present cryo-electron microscopy structures of TRPM8 in ligand-free, antagonist-bound, or calcium-bound forms, revealing how robust conformational changes give rise to two nonconducting states, closed and desensitized. We describe a malleable ligand-binding pocket that accommodates drugs of diverse chemic ...[more]