Ontology highlight
ABSTRACT:
SUBMITTER: Qiao S
PROVIDER: S-EPMC7263146 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Qiao Shuxi S Koh Siang-Boon SB Vivekanandan Varunika V Salunke Devika D Patra Krushna Chandra KC Zaganjor Elma E Ross Kenneth K Mizukami Yusuke Y Jeanfavre Sarah S Chen Athena A Mino-Kenudson Mari M Ramaswamy Sridhar S Clish Clary C Haigis Marcia M Bardeesy Nabeel N Ellisen Leif W LW
Genes & development 20200409 11-12
Human cancers with activating <i>RAS</i> mutations are typically highly aggressive and treatment-refractory, yet <i>RAS</i> mutation itself is insufficient for tumorigenesis, due in part to profound metabolic stress induced by RAS activation. Here we show that loss of REDD1, a stress-induced metabolic regulator, is sufficient to reprogram lipid metabolism and drive progression of <i>RAS</i> mutant cancers. <i>Redd1</i> deletion in genetically engineered mouse models (GEMMs) of KRAS-dependent pan ...[more]