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Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer.

ABSTRACT: Cervical cancer (CC) remains a major disease burden on the female population worldwide. Chemotherapy with cisplatin (cis-diamminedichloroplatinum (II); CDDP) and related drugs are the main treatment option for CC; however, their efficacy is limited by the development of drug resistance. Noncoding RNAs (ncRNAs) have been found to play critical roles in numerous physiological and pathological cellular processes, including drug resistance of cancer cells. In this review, we describe some of the ncRNAs, including miRNAs, lncRNAs and circRNAs, that are involved in the sensitivity/resistance of CC to CDDP-based chemotherapy and discuss their mechanisms of action. We also describe some ncRNAs that could be therapeutic targets to improve the sensitivity of CC to CDDP-based chemotherapy.

SUBMITTER: Wen X

PROVIDER: S-EPMC7263300 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer.

Wen Xin X Liu Shui S Sheng Jiyao J Cui Manhua M

PeerJ 20200529

Cervical cancer (CC) remains a major disease burden on the female population worldwide. Chemotherapy with cisplatin (<i>cis</i>-diamminedichloroplatinum (II); CDDP) and related drugs are the main treatment option for CC; however, their efficacy is limited by the development of drug resistance. Noncoding RNAs (ncRNAs) have been found to play critical roles in numerous physiological and pathological cellular processes, including drug resistance of cancer cells. In this review, we describe some of ...[more]

PMID: 32523813

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