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Road Traffic Noise Exposure and Filled Prescriptions for Antihypertensive Medication: A Danish Cohort Study.


ABSTRACT:

Background

Epidemiological research on effects of transportation noise on incident hypertension is inconsistent.

Objectives

We aimed to investigate whether residential road traffic noise increases the risk for hypertension.

Methods

In a population-based cohort of 57,053 individuals 50-64 years of age at enrollment, we identified 21,241 individuals who fulfilled our case definition of filling ?2 prescriptions and ?180 defined daily doses of antihypertensive drugs (AHTs) within a year, during a mean follow-up time of 14.0 y. Residential addresses from 1987 to 2016 were obtained from national registers, and road traffic noise at the most exposed façade as well as the least exposed façade was modeled for all addresses. Analyses were conducted using Cox proportional hazards models.

Results

We found no associations between the 10-y mean exposure to road traffic noise and filled prescriptions for AHTs, with incidence rate ratios (IRRs) of 0.999 [95% confidence intervals (CI): 0.980, 1.019)] per 10-dB increase in road traffic noise at the most exposed façade and of 1.001 (95% CI: 0.977, 1.026) at the least exposed façade. Interaction analyses suggested an association with road traffic noise at the least exposed façade among subpopulations of current smokers and obese individuals.

Conclusion

The present study does not support an association between road traffic noise and filled prescriptions for AHTs. https://doi.org/10.1289/EHP6273.

SUBMITTER: Thacher JD 

PROVIDER: S-EPMC7263450 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Publications

Road Traffic Noise Exposure and Filled Prescriptions for Antihypertensive Medication: A Danish Cohort Study.

Thacher Jesse D JD   Poulsen Aslak H AH   Roswall Nina N   Hvidtfeldt Ulla U   Raaschou-Nielsen Ole O   Jensen Steen Solvang SS   Ketzel Matthias M   Brandt Jørgen J   Overvad Kim K   Tjønneland Anne A   Münzel Thomas T   Sørensen Mette M  

Environmental health perspectives 20200514 5


<h4>Background</h4>Epidemiological research on effects of transportation noise on incident hypertension is inconsistent.<h4>Objectives</h4>We aimed to investigate whether residential road traffic noise increases the risk for hypertension.<h4>Methods</h4>In a population-based cohort of 57,053 individuals 50-64 years of age at enrollment, we identified 21,241 individuals who fulfilled our case definition of filling ≥2 prescriptions and ≥180 defined daily doses of antihypertensive drugs (AHTs) with  ...[more]

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