Ontology highlight
ABSTRACT:
SUBMITTER: Viswanathan T
PROVIDER: S-EPMC7263512 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Viswanathan Thiruselvam T Arya Shailee S Chan Siu-Hong SH Qi Shan S Dai Nan N Hromas Robert A RA Park Jun-Gyu JG Oladunni Fatai F Martinez-Sobrido Luis L Gupta Yogesh K YK
bioRxiv : the preprint server for biology 20200426
The novel severe acute respiratory syndrome coronoavirus-2 (SARS-CoV-2), the causative agent of COVID-19 illness, has caused over 2 million infections worldwide in four months. In SARS coronaviruses, the non-structural protein 16 (nsp16) methylates the 5'-end of virally encoded mRNAs to mimic cellular mRNAs, thus protecting the virus from host innate immune restriction. We report here the high-resolution structure of a ternary complex of full-length nsp16 and nsp10 of SARS-CoV-2 in the presence ...[more]