Separating dopamine D₂ and D₃ receptor sources of [¹¹C]-(+)-PHNO binding potential: Independent component analysis of competitive binding.

ABSTRACT: Development of medications selective for dopamine D₂ or D₃ receptors is an active area of research in numerous neuropsychiatric disorders including addiction and Parkinson's disease. The positron emission tomography (PET) radiotracer [¹¹C]-(+)-PHNO, an agonist that binds with high affinity to both D₂ and D₃ receptors, has been used to estimate relative receptor subtype occupancy by drugs based on a priori knowledge of regional variation in the expression of D₂ and D₃ receptors. The objective of this work was to use a data-driven independent component analysis (ICA) of receptor blocking scans to separate D₂-and D₃-related signal in [¹¹C]-(+)-PHNO binding data in order to improve the

SUBMITTER: Smart K 

PROVIDER: S-EPMC7263955 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature