Ontology highlight
ABSTRACT:
SUBMITTER: Leventhal DS
PROVIDER: S-EPMC7264239 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Nature communications 20200601 1
Synthetic biology is a powerful tool to create therapeutics which can be rationally designed to enable unique and combinatorial functionalities. Here we utilize non-pathogenic E coli Nissle as a versatile platform for the development of a living biotherapeutic for the treatment of cancer. The engineered bacterial strain, referred to as SYNB1891, targets STING-activation to phagocytic antigen-presenting cells (APCs) in the tumor and activates complementary innate immune pathways. SYNB1891 treatme ...[more]