Ontology highlight
ABSTRACT:
SUBMITTER: Yao J
PROVIDER: S-EPMC7264249 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Yao Jie J Lei Pin-Ji PJ Li Qing-Lan QL Chen Ji J Tang Shan-Bo SB Xiao Qiong Q Lin Xiang X Wang Xiang X Li Lian-Yun LY Wu Min M
Oncogenesis 20200601 5
Gene transcription is coordinately regulated by multiple transcription factors. However, a systematic approach is still lacking to identify co-regulators for transcription factors. Here, we performed ChIP-Seq analysis and predicted the regulators for p53-mediated transcription process, from which we confirmed the roles of GLIS2, MAZ and MEF2A in regulating p53 target genes. We revealed that GLIS2 selectively regulates the transcription of PUMA but not p21. GLIS2 deficiency caused the elevation o ...[more]