Ontology highlight
ABSTRACT:
SUBMITTER: Yin X
PROVIDER: S-EPMC7264337 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Yin Xue X Motorwala Aarif A Vesvoranan Oraya O Levene Howard B HB Gu Weiyong W Huang Chun-Yuh CY
Scientific reports 20200601 1
As the most common cause of low back pain, the cascade of intervertebral disc (IVD) degeneration is initiated by the disappearance of notochordal cells and progressive loss of proteoglycan (PG). Limited nutrient supply in the avascular disc environment restricts the production of ATP which is an essential energy source for cell survival and function such as PG biosynthesis. The objective of this study was to examine ATP level and PG production of porcine IVD cells under prolonged exposure to hyp ...[more]