Ontology highlight
ABSTRACT:
SUBMITTER: Koul A
PROVIDER: S-EPMC7264852 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Koul Amit A Gemmill Darren D Lubna Nikhat N Meier Markus M Krahn Natalie N Booy Evan P EP Stetefeld Jörg J Patel Trushar R TR McKenna Sean A SA
Biophysical journal 20200501 11
Oligoadenylate synthetases (OASs) are a family of interferon-inducible enzymes that require double-stranded RNA (dsRNA) as a cofactor. Upon binding dsRNA, OAS undergoes a conformational change and is activated to polymerize ATP into 2'-5'-oligoadenylate chains. The OAS family consists of several isozymes, with unique domain organizations to potentially interact with dsRNA of variable length, providing diversity in viral RNA recognition. In addition, oligomerization of OAS isozymes, potentially O ...[more]