Association Between Fexofenadine Use During Pregnancy and Fetal Outcomes.

ABSTRACT:

Importance

Fexofenadine hydrochloride is a frequently used drug for treatment of allergic conditions during pregnancy, but the fetal safety of fexofenadine use has not been well studied.

Objective

To investigate the risk of adverse fetal outcomes associated with fexofenadine use during pregnancy.

Design, setting, and participants

A nationwide registry-based cohort study was conducted on pregnancies in Denmark from January 1, 2001, to December 31, 2016. Data analysis was performed from March 21, 2019, to January 29, 2020. From a cohort of 1 287 668 pregnancies, fexofenadine use was compared with cetirizine hydrochloride use during pregnancy, matched in a 1:1 ratio on propensity scores. Distinct study cohorts and exposure time periods were applied according to each outc

SUBMITTER: Andersson NW 

PROVIDER: S-EPMC7265125 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature