Ontology highlight
ABSTRACT:
SUBMITTER: Liu YJ
PROVIDER: S-EPMC7265311 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Liu Yasmine J YJ McIntyre Rebecca L RL Janssens Georges E GE Williams Evan G EG Lan Jiayi J van Weeghel Michel M Schomakers Bauke B van der Veen Henk H van der Wel Nicole N NN Yao Pallas P Mair William B WB Aebersold Ruedi R MacInnes Alyson W AW Houtkooper Riekelt H RH
The Journal of cell biology 20200601 6
Mitochondrial form and function are closely interlinked in homeostasis and aging. Inhibiting mitochondrial translation is known to increase lifespan in C. elegans, and is accompanied by a fragmented mitochondrial network. However, whether this link between mitochondrial translation and morphology is causal in longevity remains uncharacterized. Here, we show in C. elegans that disrupting mitochondrial network homeostasis by blocking fission or fusion synergizes with reduced mitochondrial translat ...[more]