Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells.
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ABSTRACT:
SUBMITTER: Cheteh EH
PROVIDER: S-EPMC7265343 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells.
Cheteh Emarndeena H EH Sarne Victoria V Ceder Sophia S Bianchi Julie J Augsten Martin M Rundqvist Helene H Egevad Lars L Östman Arne A Wiman Klas G KG
Cell death discovery 20200602
Cancer-associated fibroblasts (CAFs) promote tumor growth and progression, and increase drug resistance through several mechanisms. We have investigated the effect of CAFs on the p53 response to doxorubicin in prostate cancer cells. We show that CAFs produce interleukin-6 (IL-6), and that IL-6 attenuates p53 induction and upregulation of the pro-apoptotic p53 target Bax upon treatment with doxorubicin. This is associated with increased levels of MDM2 mRNA, Mdm2 protein bound to p53, and ubiquiti ...[more]
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