Ontology highlight
ABSTRACT:
SUBMITTER: Green KY
PROVIDER: S-EPMC7265440 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Green Kim Y KY Kaufman Stuart S SS Nagata Bianca M BM Chaimongkol Natthawan N Kim Daniel Y DY Levenson Eric A EA Tin Christine M CM Yardley Allison Behrle AB Johnson Jordan A JA Barletta Ana Beatriz F ABF Khan Khalid M KM Yazigi Nada A NA Subramanian Sukanya S Moturi Sangeetha R SR Fishbein Thomas M TM Moore Ian N IN Sosnovtsev Stanislav V SV
Nature communications 20200602 1
Human noroviruses are a major cause of diarrheal illness, but pathogenesis is poorly understood. Here, we investigate the cellular tropism of norovirus in specimens from four immunocompromised patients. Abundant norovirus antigen and RNA are detected throughout the small intestinal tract in jejunal and ileal tissue from one pediatric intestinal transplant recipient with severe gastroenteritis. Negative-sense viral RNA, a marker of active viral replication, is found predominantly in intestinal ep ...[more]