Unknown

Dataset Information

0

Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms.


ABSTRACT: Malaria parasites complete their intra-erythrocytic developmental cycle (IDC) in multiples of 24?h suggesting a circadian basis, but the mechanism controlling this periodicity is unknown. Combining in vivo and in vitro approaches utilizing rodent and human malaria parasites, we reveal that: (i) 57% of Plasmodium chabaudi genes exhibit daily rhythms in transcription; (ii) 58% of these genes lose transcriptional rhythmicity when the IDC is out-of-synchrony with host rhythms; (iii) 6% of Plasmodium falciparum genes show 24?h rhythms in expression under free-running conditions; (iv) Serpentine receptor 10 (SR10) has a 24?h transcriptional rhythm and disrupting it in rodent malaria parasites shortens the IDC by 2-3?h; (v) Multiple processes including DNA replication, and the ubiquitin and proteasome pathways, are affected by loss of coordination with host rhythms and by disruption of SR10. Our results reveal malaria parasites are at least partly responsible for scheduling the IDC and coordinating their development with host daily rhythms.

SUBMITTER: Subudhi AK 

PROVIDER: S-EPMC7265539 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms.

Subudhi Amit K AK   O'Donnell Aidan J AJ   Ramaprasad Abhinay A   Abkallo Hussein M HM   Kaushik Abhinav A   Ansari Hifzur R HR   Abdel-Haleem Alyaa M AM   Ben Rached Fathia F   Kaneko Osamu O   Culleton Richard R   Reece Sarah E SE   Pain Arnab A  

Nature communications 20200602 1


Malaria parasites complete their intra-erythrocytic developmental cycle (IDC) in multiples of 24 h suggesting a circadian basis, but the mechanism controlling this periodicity is unknown. Combining in vivo and in vitro approaches utilizing rodent and human malaria parasites, we reveal that: (i) 57% of Plasmodium chabaudi genes exhibit daily rhythms in transcription; (ii) 58% of these genes lose transcriptional rhythmicity when the IDC is out-of-synchrony with host rhythms; (iii) 6% of Plasmodium  ...[more]

Similar Datasets

2020-04-20 | GSE132647 | GEO
2020-04-20 | GSE144976 | GEO
2020-04-20 | GSE132643 | GEO
2020-04-20 | GSE132625 | GEO
| S-EPMC9285586 | biostudies-literature
| PRJNA605476 | ENA
| PRJNA548568 | ENA
| PRJNA548570 | ENA
| PRJNA548549 | ENA
| S-EPMC2268965 | biostudies-literature