Ontology highlight
ABSTRACT:
SUBMITTER: Subudhi AK
PROVIDER: S-EPMC7265539 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Nature communications 20200602 1
Malaria parasites complete their intra-erythrocytic developmental cycle (IDC) in multiples of 24 h suggesting a circadian basis, but the mechanism controlling this periodicity is unknown. Combining in vivo and in vitro approaches utilizing rodent and human malaria parasites, we reveal that: (i) 57% of Plasmodium chabaudi genes exhibit daily rhythms in transcription; (ii) 58% of these genes lose transcriptional rhythmicity when the IDC is out-of-synchrony with host rhythms; (iii) 6% of Plasmodium ...[more]