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SARS-CoV-2 infection: The role of cytokines in COVID-19 disease.

ABSTRACT: COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-?, and TNF-?, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19.

SUBMITTER: Costela-Ruiz VJ

PROVIDER: S-EPMC7265853 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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SARS-CoV-2 infection: The role of cytokines in COVID-19 disease.

Costela-Ruiz Víctor J VJ Illescas-Montes Rebeca R Puerta-Puerta Jose M JM Ruiz Concepción C Melguizo-Rodríguez Lucia L

Cytokine & growth factor reviews 20200602

COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients w ...[more]

PMID: 32513566

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