Ontology highlight
ABSTRACT:
SUBMITTER: Hamodi AS
PROVIDER: S-EPMC7266618 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Hamodi Ali S AS Martinez Sabino Aude A Fitzgerald N Dalton ND Moschou Dionysia D Crair Michael C MC
eLife 20200518
Convenient, efficient and fast whole-brain delivery of transgenes presents a persistent experimental challenge in neuroscience. Recent advances demonstrate whole-brain gene delivery by retro-orbital injection of virus, but slow and sparse expression and the large injection volumes required make this approach cumbersome, especially for developmental studies. We developed a novel method for efficient gene delivery across the central nervous system in neonatal mice and rats starting as early as P1 ...[more]