Ontology highlight
ABSTRACT:
SUBMITTER: Pavlos R
PROVIDER: S-EPMC7266722 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Pavlos Rebecca R Deshpande Pooja P Chopra Abha A Leary Shay S Strautins Kaija K Nolan David D Thorborn Daren D Shaefer Mark M Rauch Andri A Dunn David D Montaner Julio J Rachlis Anita A Almeida Coral-Ann CA Choo Linda L James Ian I Redwood Alec J AJ Li Yueran Y Gaudieri Silvana S Mallal Simon A SA Phillips Elizabeth J EJ
Human immunology 20200312 6
Abacavir hypersensitivity syndrome (ABC HSS) is strongly associated with carriage of human leukocyte antigen (HLA)-B*57:01, which has a 100% negative predictive value for the development of ABC HSS. However, 45% of individuals who carry HLA-B*57:01 can tolerate ABC. We investigated immune and non-immune related genes in ABC HSS (n = 95) and ABC tolerant (n = 43) HLA-B*57:01 + patients to determine other factors required for the development of ABC HSS. Assignment of phenotype showed that ABC HSS ...[more]